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Yellow fever (also called yellow jack, black vomit or vomito *****, or sometimes American Plague) is an acute viral disease. It is an important cause of hemorrhagic illness in many African and South American countries despite existence of an effective vaccine. The yellow refers to the jaundice symptoms that affect some patients.
There is no true cure for yellow fever, therefore vaccination is important. Treatment is symptomatic and supportive only. Fluid replacement, fighting hypotension and transfusion of blood derivates is generally needed only in severe cases. In cases that result in acute renal failure, dialysis may be necessary. A fever victim needs to get lots of rest, fresh air, and drink plenty of fluids.
Yellow fever is caused by a virus that is spread by the Aedes aegypti mosquito. These mosquitoes thrive in and near human habitations where they breed in even the cleanest water. Most cases of yellow fever occur in sub-Saharan Africa and tropical South America.
In urban yellow fever, virus is transmitted by the bite of an Aedes aegypti mosquito infected about 2 wk previously by feeding on a viremic person. In jungle (sylvatic) yellow fever, the virus is transmitted by Haemagogus and other forest canopy mosquitoes that acquire the virus from wild primates. Incidence is highest during months of peak rainfall, humidity, and temperature in South America and during the late rainy and early dry seasons in Africa.
Humans and monkeys are most commonly infected with the yellow fever virus. Mosquitoes transmit the virus back and forth between monkeys, humans or both. When a mosquito bites a human or monkey infected with yellow fever, the virus enters the mosquito's bloodstream and circulates before settling in the salivary glands. When the infected mosquito then bites another monkey or human, the virus then enters the host's bloodstream, where it may cause the serious illness.
Traveling to an area in which the yellow fever virus is known to be present puts you at risk of the disease. These areas include sub-Saharan Africa and tropical South America.
Even if there aren't current reports of infected humans in these areas, it doesn't mean you're risk-free. It's possible that local populations have been vaccinated and so are protected from the disease, or that cases of yellow fever just haven't been detected and officially reported.
If you're planning on traveling to these areas, you can protect yourself by getting a yellow fever vaccine at least 10 to 14 days prior to traveling.
Anyone can be infected with the yellow fever virus, but older adults are at greater risk of getting seriously ill.
The most effective way to prevent outbreaks is to reduce the number of mosquitoes and limit mosquito bites by using diethyltoluamide (DEET), mosquito netting, and protective attire. During jungle outbreaks, people should evacuate the area until they are immunized and mosquitoes are controlled. For people traveling to endemic areas, active immunization with the 17D strain of live, attenuated yellow fever vaccine (0.5 mL sc q 10 yr) is indicated and is effective in 95%. In the US, the vaccine is given only at US Public Health Service鈥揳uthorized Yellow Fever Vaccination Centers. The vaccine is contraindicated in pregnant women and in those with compromised immunity.
To prevent further mosquito transmission, infected patients should be isolated in rooms that are well screened and sprayed with insecticides

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