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In Type II diabetes, cells throughout the body are resistant to insulin鈥檚 uptake..? |
In Type II diabetes, cells throughout the body are resistant to insulin鈥檚 uptake why do then they are given insulin injection or tablets? Tablets can improve the way your own insulin works (metformin, glitazones), or make you produce more insulin to overcome the resistance (sulphonylureas) -in the latter case, think of it in this way: in a healthy person, insulin has 100% effect in peripheral tissues. In an insulin resistant person (the main underlying pathology in Type 2 Diabetes) this insulin only has 50% effect in tissues. So, if you have 200% of normal insulin level circulating in your blood, you will achieve the same desired 100% effect. Likewise with insulin injections. Type 2 just means the insulin doesn't work as well as it should because of age, history, lifestyle etc. The tablets and injections either act as a source of more efficient insulin or they boost the insulin the person already produces so the insulin can do it's job better. "Type 2 diabetes is a disease in which your pancreas does not produce enough insulin, or your body does not properly use the insulin it makes. In my case, my body doesn't use the insulin it makes naturally. I am on 2 different types of insulin injections. I know it sounds crazy, if I have insulin I'm not using why take more....the answer I have from the doctor is the injected insulin is easier for my body to use than the natural insulin and it gives my body a break from trying so hard to keep making more and more insulin because my sugar is high. My glands don't know that I'm not using what's being made naturally. All the glands know is high sugar equals make more insulin...sooner or later your body will give out and not be able to keep up with that rate of insulin production...supplementing with injections makes your sugar go down and then you glands say, hey....we can take a break...she has enough insulin right now. My goal is to get off the injections in time and for that I will need my body to be capable of still making it's own insulin.. In type 2 either the insulin produced by the body doesn't work as well as it should or the body doesn't produce enough. Medications for type 2 diabetes work in several different ways. The medication that I take, causes the pancreas to produce more insulin. It seems to be working for me but it does not work for everyone. There are several classes of oral anti-diabetics that work in different ways. Encouraging more insulin production is more of last resort. |
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