Help me in differentiating the thrombocytopenia induced by Chemotherapy and DIC synd? What r diff diagnostics?

Could someone help me to differentiate the thrombocytopenia induced by Chemotherapy and DIC syndrome? What are the differential diagnostics?

I searched all through the literature.. Found no satisfying answers..

Would welcome suggestions from fellow colleagues and references to articles..

Thanks in advance..

Thrombocytopenia induced by chemotherapy and DIC are different in that the former is generally caused by myelosuppression (defect in production), and the later is caused by a problem with excessive destruction. Keeping this in mind, generally, chemoinduced thrombocytopenia (CIT) should have little to no evidence of peripheral destruction on the peripheral blood smear, while DIC will show evidence of intravascular lysis of cells, this may include hemolysis (as manifested by schistocytes, rbc fragments) in addition to platelet destruction. Therefore, DIC will also show evidence of hemolysis such as elevated LDH/lowered haptoglobin (though the LDH may be elevated by tumor lysis syndrome in chemotherapy). The ultimate diagnostic test, would be a bone marrow biopsy, indicating either presence of megakaryopoiesis (in DIC) or lack there of (in CIT). Of course, a good clinical history and exam is usually helpful.

thrombocytopenia resulted from DIC usually can be physically examined by looking at your skin...if there is any red rash...

and if you have been in chemotheraphy than it should be the main reason as the chemical effect the platlet formation in bone marrow...

if you haven't been in chemotherapy maybe you should choose the other possibilities