What is the cause of refractory thrombocytopenia?

I take it that you mean "refractory to transfusions"?

In patients who have had many platelet transfusions, a syndrome can develop in which the persons immune system develops antibodies to foreign platelets. The immune system destroys the new platelets as fast as they are run in. There is no strict algorithem for who will develop this problem, but in general: the more transfusions, the greater the risk.

Getting HLA matched platelets can be a big help if a person becomes refractory. I'm not sure if it would help to prevent it, but it is not generally done as a preventative measure (at least at my hospital).

1. Patients on chemotherapy

Tags

　　Thyroid Diseases 　　Thyroid Cancer 　　Thymus Cancer 　　Thumb Injuries 　　Thrush 　　Thrombophlebitis 　　Thrombocytopenia 　　Throat Disorders 　　Throat Cancer 　　Thoracic Outlet Syndrome 　　Thiamine 　　Thalassemia 　　Tetanus

Related information

World wide incidence of acquired amegakaroycitic thrombocytopenia?

In the US the frequency has been reported to be 1-2 cases per 1000 deliveries (Burrows, 1990). It can be diagnosed during pregnancy, though, most often, women present for prenatal care with a histo...

ITP - do I have a concern?

If it were me I would be asking for more tests to determine why you have the petechiae and bruising...they are not normal and something is going on (even if it isn't thrombocytopenia purpura)<...

My doctors are stumped, and I would appreciate an opinion on a very unusual case.?

A diagnosis is made as follows : 75% from history n 25% from physical examination n lab tests. U have mentioned only lab stuff . What are the peripheral blood smear findings ??Elevated H...