World wide incidence of acquired amegakaroycitic thrombocytopenia?

In the US the frequency has been reported to be 1-2 cases per 1000 deliveries (Burrows, 1990). It can be diagnosed during pregnancy, though, most often, women present for prenatal care with a history of the disorder.

The frequency is estimated at 1-2 cases per thousand deliveries.

Internationally: The frequency is 1.8 cases per 1000 deliveries in Helsinki, Finland (Sainio, 2000). The frequency was reported as 0.5 cases per 1000 and 1.5 cases per 1000 liveborn neonates in England (Blanchette, 1990) and France (Dreyfus, 1997), respectively.

In Japan, the frequency was 0.3 cases per 1000 liveborn neonates, and incompatibility for human platelet antigen (HPA)-4 was the cause of 80% of these cases (Davis, 1998).

The recurrence risk is extremely high (nearly 100% of subsequent pregnancies are affected if the sibling carries the significant paternally derived antigen) (Bussel, 1997). In general, siblings with the platelet antigen will be as severely affected or more severely affected than the preceding affected child (Bussel, 1997).


I thought this was something that was more common in canine patients but I might be wrong.

oh noooo AAT!!!
can misquitos trasmit it!
Can you get it from toilet seats too!
MIKE

What's that worth in Scrabble?

Oh wow, now I'm worried.