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Syphilis...?


What is the size of the inoculum for Treponema pallidum? This is the bacteria that causes syphilis. I have searched high and low for this darn answer and can't find it anywhere. The size of inoculum means how many single bacteria it takes to transmit the disease. Any help and references to the site you found it in will be greatly appreciated!

try

http://www.horizonpress.com/jmmb/v3/v3n1...

it is a fairly complete treatment

also

http://cmr.asm.org/cgi/content/full/19/1...

T pallidum is inoculated via 1 of the routes described above. The infectious dose varies from patient to patient, but in rabbits as few as 4 treponemes can establish infection. 17 Within hours to days, spirochetes disseminate from the local inoculation site via the bloodstream and lymphatics. Lesions will appear once 107 organisms per gram of tissue have been achieved. 17 The incubation period varies, depending on the inoculum size.

They do not do human experiments with this bacteria, only on animals, specically rabbits. This is the best I could find.

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