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Bacteria- sepsis?


Why gram-positive sepsis is not as common today as gram-negative sepsis? And why is gram-negative sepsis so dangerous compared to gram-positve sepsis?

gram negative sepsis is more dangerous because of the presence of LPS in the outer membrane of the bacteria, it is not found in gram positive bacteria.

LPS is a very potent antigen and the presence of large amounts of it, especially in the blood stream can lead to a person going into shock.

Many gram negative bacteria can just shed LPS into the environment (blood stream in this case), but you also have to worry about massive lysis of the bacteria doing the same thing. This requires a certain amount of care in administration of the antibiotics so you don't send the patient into shock that way, as well.

I don't agree with the antibiotic comments either. When they talk about antibiotic resistant bacteria becomming a threat, it's stuff like Staph aureus and Enterococcus, both gram positive bacteria. Antibiotic associated diarrhea is caused by Clostridium difficile (most frequently) and C. perfringens (less frequently), both gram positive bacteria.

Gram positive bacteria are easier to kill with common antibiotics. They can be avoided by using good hygiene practices. Gram negative bacteria produce toxins which can cause breakdown of red blood cells, blood poisoning and shock due to dilatation of small blood vessels.

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