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What are the top five rarest diseases in the world?


Please provide documentation if possible.

1. Hutchinson-Gilford Progeria
2. Fanconi anemia
3. Landau Kleffner Syndrome
4. Wilson's Disease
5. Canavan disease
6. fibrodysplasia osssificans progressiva (FOP)

threw in an extra for ya!

The G-Unit disease. Extremely Rare

There are many cases with one-of-a-kind diagnoses which cannot even be classified with present knowledge.

A known disease which has not occurred for many years is smallpox, but there's no warranty that it may be present in some remote area.

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