What is the target volume in radiation therapy in brain stem gliomas?

. A mean total dose of 54 Gy was given in daily fractions of 1.8 Gy. Median follow-up was 12 months.Results: . Neurological improvement was achieved in 19/38 patients. Reduction of tumour size was reported in 12/38, in 16 patients the lesion was unchanged, ten showed progression. Median time to progression was 23 months, median overall survival 40 months with an actuarial survival of 83% at 1 year, 55% at 3 years and 33% at 5 years. In 20 of 22 patients with recurrence progression was inside the target volume. Significant prognostic factors for survival were clinical and radiological response 6 weeks after FSRT. Treatment toxicity was mild. Ototoxicity occurred in one patient.Conclusions: FSRT is a feasible treatment modality for BSG with tolerable toxicity. The risk of marginal failure is low.

Keywords: Brain stem glioma; Fractionated stereotactic radiotherapy; Radiation therapy

They usually target just the abnormal brain they see on the MRI that diagnosed the problem with 1-2 cm additional to cover set up errors.

It's a terrible malignancy. :(

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