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Diabetic neuropathy? |
role of ssri in diabetic neuropathy Treatment of early manifestations of sensorimotor polyneuropathy involves improving glycemic control. Tight control of blood glucose can reverse the changes of diabetic neuropathy. Despite advances in the understanding of the metabolic causes of neuropathy, treatments aimed at interrupting these pathological processes have been limited by side effects and lack of efficacy. . The drugs- imipramine, amitriptyline, desipramine and nortriptyline- are effective at decreasing painful symptoms but suffer from multiple side effects that are dosage dependent. One notable side effect is cardiac toxicity, which can lead to fatal arrhythmias. The only med that I have heard that is effective for diabetic neuropathy is Cymbalta, which is actually acts on serotonin and norepinephrine receptors. In fact, I believe it has been labeled for this use. Probably at the 90 mg dose. Try this: SSRI means 'selective serotonin reuptake inhibitors' and is a class of medications used for treating diabetic neuropathy. Diabetic neuropathy means the damage to the nerves that can happen with diabetes. Here is a link about that: Please see Google search for more details on Diabetic neuropathy and Selective serotonin reuptake inhibitors (SSRI) drug. Consult a Diabetologist. are u asking if SSRI can be beneficial for patients with diabetic neuropathy, or SSRI increasing diabetic neuropathy? ask again....u might generate more answers Paxil (paroxetine hydrochloride) is an SSRI that is also used to treat diabetic neuropathy, usually 40mg/daily. It's action is to inhibit serotonin reuptake, hence the classification SSRI (selective serotonin reuptake inhibitors). In the central nervous system, serotonin acts as a neurotransmitter. Neurotransmitters transmit nerve impulses (messages) in a sort of relay system to the brain where they are interpreted as pain (as in the case of neuropathies). To make it simple, if serotonin is controlled, less pain is felt. SSRIs or Selective Serotonin Reuptake Inhibitors are a group of drugs mainly used in treating depression, but recent trials have indicated that they may be useful in treating diabetic neuropathy as well, due to their action on GABA receptors. Try lipoic acid 300-600 mg a day. Doctors are using it in Europe and getting good results. Give it a couple of months to kick in. use Ganoderma the natural herb and Magno the natural health drink and live healthy life. I would go with natural therapy. Below is a link to a supplement called pycnogenol. Check it out... it's very promising. Also, you might want to read the rest as an ounce of prevention is worth a pound of cure... No one mentioned Neurotin, Gabapendin that blocks pain impulses. you need to be on paxil it helps so much better then anything out there my mother unfortunatly has neuropathy-she takes neurotin for the tremendous pain she is in.There is no cure for neuropathy and some people have it worse than others.Both my moms parents had diabetes and neuropathy but she is worse off-they all have(had)CHF,PAD.My mom is 52 years old and b/c she has had 5 heart attacks and 3 strokes her heart is working at 20% now.Doctors have said if she has a big heart attack it will take her life b/c she is so weak.Best wishes |
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