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Neurofibromatosis Type 1 and 2?


I am wondering what the differences between type one and two NF (neurofibromatosis) are. Could someone please explain to me what they are? I would appreciate it. I don't have this disease, but I know someone who does.

The person I know who has this has the brown coffee-colored spots on the body, acts like a six-year-old, and it can cause her to get tumors.

Neurofibromatosis type 1 - mutation of neurofibromin chromosome 17q11.2 (Incidence is 1:3500)
* multiple neurofibromas on the skin and under the skin; the subcutaneous lumps are characteristic of the disease and increase in number with age.
* freckling of the groin and the arm pit.
* a predisposition to particular tumors (both benign and malignant). These tumors are called neurofibromas.
* Caf茅 au lait spots (pigmented birthmarks). Six or more of these form one of the diagnostic criteria, but are not essential for diagnosis.
* skeletal abnormalities such as scoliosis or bowing of the legs might occur
* Lisch nodules (hamartomas of iris)
* tumor on the optic nerve, also known as an Optic Glioma.

Neurofibromatosis type 2 - mutation of merlin chromosome 22q12. It is a genetic disorder that causes tumors to form on the nerves of the brain and spine (the central nervous system). Incidence is 1:40,000.
* bilateral tumors, acoustic neuromas on the vestibulocochlear nerve
* the hallmark of NF 2 is hearing loss due to acoustic neuromas around the age of twenty
* the tumors may cause:
headache
balance problems, and Vertigo
facial weakness/paralysis
patients with NF2 may also develop other brain tumors, as well as spinal tumors
Deafness and Tinnitus

Well I have type one which is more common. One would never know I had NF, I just have the cafe'au spots am sure I spelt it wrong sorry, psedouortosis in my right leg, and freakling under my armpits and groin region. This can also cause one to get fatty tumors. With type two it is a little more server. They can have some deformaty due to the fatty tumors and the like. Sorry thats it I really know. Sometimes it is mistaken as Von Reckins or elephant man...

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