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Has anyone heard of the muscle condition 'Central Core Myopathy'?


Has anyone heard of the muscle condition 'Central Core Myopathy'?

Central core disease is a type of congenital myopathy where there is absence of organelles and myofibrils in the central
cores of muscle fibres. The disease is characterized by the presence of myofibrillar cores which are best demonstrated by oxidative enzyme histochemistry. An important feature of the disease is its close association with malignant hyperthermia. Central core disease is a slowly progressing skeletal muscle disorder that, unlike most of the muscular dystrophies, is not life-threatening. It is called central core disease because the muscle cells associated with the disease have an abnormal light inner core surrounded by a dark circle. Central core disease develops before early infancy and its symptoms include hip displacement, an inability to jump and run smoothly, and general weakening of the muscles. Associated symptoms and findings may include abnormally diminished muscle tone (hypotonia), potentially resulting in unusual "floppiness" of muscles; muscle weakness; delays in motor development, such as in walking; and/or, in some cases, associated musculoskeletal problems, such as dislocation of the hips at birth (congenital). CCD may also be associated with susceptibility to malignant hyperthermia, a potentially life-threatening reaction to certain anesthetics or skeletal muscle relaxants.

I have heard of central core disease, which is a myopathy. It causes mild weakness. See the sources below for more information about central core disease.

If you or a loved one has central core disease, it is extremely important to let the anesthesiologist know prior to any surgery, as people with this condition are susceptible to a serious problem triggered by anesthetic drugs (malignant hyperthermia). If the anesthesiologist knows, he/she can use other drugs that are safe in this condition.

nope i havent

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