Does myasthenia gravis get worse the older you get or the longer yo have it?

i have had mg for 13 yrs now and it seems as if my symptoms are getting worse. or like i am depending more on devices to mobilize myself. could it be something else has come about? they say most have other underlying conditions? i want those who have dealt with the disease pesonally to answer, dr,family member or personally have it.

Here is a site that has personal experiences on it plus another site that lists the basics of the disease. Good luck

What is Myasthenia Gravis?
Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. The hallmark of myasthenia gravis is muscle weakness that increases during periods of activity and improves after periods of rest. Muscles that control eye and eyelid movements, facial expression, chewing, talking, and swallowing are often, but not always, involved. The muscles that control breathing and neck and limb movements may also be affected. Myasthenia gravis is caused by a defect in the transmission of nerve impulses to muscles. Normally when impulses travel down the nerve, the nerve endings release a neurotransmitter substance called acetylcholine. In myasthenia gravis, antibodies produced by the body's own immune system block, alter, or destroy the receptors for acetylcholine. The first noticeable symptoms of myasthenia gravis may be weakness of the eye muscles, difficulty in swallowing, or slurred speech. Symptoms vary in type and severity. Myasthenia gravis is not directly inherited nor is it contagious. The first steps in diagnosing myasthenia gravis include a review of the individual's medical history and physical and neurological examinations. If the doctor suspects myasthenia gravis, several diagnostic tests are available to confirm the diagnosis, including a special blood test that can detect the presence of immune molecules or acetylcholine receptor antibodies.

Is there any treatment?


Myasthenia gravis can be controlled. Some medications improve neuromuscular transmission and increase muscle strength, and some suppress the production of abnormal antibodies. These medications must be used with careful medical followup because they may cause major side effects. Thymectomy, the surgical removal of the thymus gland (which often is abnormal in myasthenia gravis patients), improves symptoms in certain patients and may cure some individuals, possibly by re-balancing the immune system. Other therapies include plasmapheresis, a procedure in which abnormal antibodies are removed from the blood, and high-dose intravenous immune globulin, which temporarily modifies the immune system and provides the body with normal antibodies from donated blood.

What is the prognosis?


With treatment, the outlook for most patients with myasthenia is bright: they can expect to lead normal or nearly normal lives. Some case of myasthenia gravis may go into remission temporarily, and muscle weakness may disappear so that medications can be discontinued. In a few cases, the severe weakness of myasthenia gravis may cause respiratory failure, which requires immediate emergency medical care.

What research is being done?


Scientists are evaluating new and improving current treatments for myasthenia gravis. One study is testing the efficacy of intravenous immune globulin, and another study seeks to understand the molecular basis of synaptic transmission in the nervous system.

Select this link to view a list of studies currently seeking patients.

Organizations

Myasthenia Gravis Foundation of America, Inc.
1821 University Ave W.
Suite S256
St. Paul, MN 55104-2897
mgfa@myasthenia.org
http://www.myasthenia.org
Tel: 800-541-5454 651-917-6256
Fax: 651-917-1835

Muscular Dystrophy Association
3300 East Sunrise Drive
Tucson, AZ 85718-3208
mda@mdausa.org
http://www.mda.org
Tel: 520-529-2000 800-344-4863
Fax: 520-529-5300



Related NINDS Publications and Information

Myasthenia Gravis Fact Sheet

Myasthenia Gravis information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS

web,md