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Has anyone had M Protein found in their bloodwork and not had Multiple Myeloma?


My gram had bloodwork last week and they found the M Protein in it which could indicate Multiple Myeloma. We've also heard it can indicate soft tissue tumors. She has an appointment with the hematologist in 2 weeks to find out more. I just was wondering if anyone else had this show up in their bloodwork and they didn't have Multiple Myeloma. Any encouraging stories would be great! My gram is only 63 and raised me, so I am very worried.

M proteins refer to an elevation in a particular immunoglobulin (the antibodies that our white cells make to fight infections and what-not). Most of the time this elevation is termed polyclonal in that all of the immunoglobulins are elevated. The "M" refers to a monoclonal spike, or the immunoglobulins from just one clone of white blood cells.

It is far, far more common to see people with M proteins who do NOT have multiple myeloma. The most common condition is termed MGUS, or monoglonal gammopathy of uncertain significance. We know that, over time, patients might develop myeloma, but there is no evidence to suggest that any sort of treatment is indicated for that condition.

It is important that she undergo the appropriate tests to completely exclude myeloma and discuss her treatment options with her hematologist.

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