In Multiple myeloma,for how long therapy with biphosphonates should be continued?

A pt of Stage 2 myeloma is on chemotherapy with Thallix and Dexa.(Fifth cycle)and has received 3 injections of Zolindronic acid ,is on remission(4% plasma cells).feeling some bone pains now a days.Are they due to discontinuing Biphosphonates?

There is no formula for how long before they become un effective.

It is vary patient dependant - most people get toxic before the drug fails (side effects from thal / dex are well known).

Since he is doing "well" may want to go to a low dose and see what happens.

the bigger issue is the dex - the steroid is really hard on the body - steroid induced diabeties is not uncommon and it ruins joints and kidneys.

check mmrf and imf websites for drug "norm" charts.

good luck

Jewells
35 months and still here

Tags

　　Myasthenia Gravis 　　Muscular Dystrophy 　　Muscle Strain 　　Muscle Disorders 　　Mumps 　　Multiple Sclerosis 　　Multiple Myeloma 　　Multiple Endocrine Neoplasia 　　Multiple Births 　　Mucopolysaccharidoses 　　Mucolipidoses 　　MRSA 　　MRI Scans

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