What are the co-factors of mental retardation that cause retarded people to, well, look retarded?

Don't beat me up for the question, it's sincere.

The extra chromosome. It changes a lot about a person's mental capabilities and physical appearance.

You're possibly thinking of Down syndrome, which is caused by an extra chromosome.
BTW, just because someone has a developmental challenge(proper term is developmentally challenged, don't use 'retarded')does not mean they can't have a meaningful life.

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