Mental health. Venlafaxine/Efexor. Why is it better than other Antidepressants? I took Effexor for years and yes it did seem to work but to be honest it made me feel numb. I tried different therapies and ended up going for the natural therapies which have been awesome for me. well their is wellbutrin xl,sr i take the sr and it is a generic one well dose the generic work or the real medicine In general there in no one antidepressant that is 'better' than any other. Different medications affect people in various manners, it can depend on the type of depression you have, the severity and the length of time you have been suffering. It is best to discuss the different medications with your doctor as they will know what is appropriate for your situation. Also if you feel something is not working for you or that the negative side effects are worse than the depression itself tell your doctor and they can always try you on a different drug. | 