The statistical possibilities a Maffucci's disease come to malignancy. Especially when it was manipulated.

Maffucci's disease is a bone disease. It is enchondroma with angiogenesis. Surgical therapy is applied only if indicated. There was a possibilites to be malignant, an enchondroma after a surgical manipulation. Is there any data of the incidence of malignancy after surgical manipulation?

Here you go-

"Approximately 30-37% of enchondromas can develop into a chondrosarcoma.

Neoplastic changes occur in enchondromas. Chondrosarcoma is the most common neoplasm in this syndrome, affecting about 30% of patients. The average age for neoplastic change is 40 years. Vascular neoplasms have occurred in 4 reported cases: 2 hemangiosarcomas and 2 lymphangiosarcomas."

But the disease is so rare-

"Maffucci syndrome is rare. Fewer than 100 cases have been reported in the United States."

"Maffucci syndrome is rare, with about 160 total case reports in the English literature."

The population is tiny and only gives a rough idea.

On top of that, I found nothing that stated specifically these figures apply post-surgery.

The one hint is that Maffaucci himself originally identified this in a female following the amputation of her arm, and she later died.

The figures may all apply to post operative malignant changes.

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