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What is the real cause of thrombocytopenia in most malaria patients? |
i'm doing a graduation project on thrombocytopenia in Malaria. and i got 90 cases +ve with malaria and 65 of them having thrombocytopenia. i just want to know the cause of this phenomena. and what's the relation between paltelet and malaria? The Plasmodium species(the parasite that causes malaria) have no direct effect on platelets. Instead Plasmodium attacks red blood cells (RBCs) and when the are damaged they are trapped by the spleen which filters the blood. Because there are so many RBCs damaged the spleen takes up an unusually high number of RBCs and becomes enlarged (splenomegaly). The platelets get trapped in the now clogged spleen and this causes the thrombocytopenia. I think it has to do with the bone marrow don't produce enough platelets |
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