What health risks can be attributed to UNADULTERATED LSD (acid), Psilocybin (mushrooms), or MDMA (ecstasy)?

Most discussion of the health risks associated with taking LSD, Psilocybin, and MDMA seems to center around the danger of harmful chemicals being sold as or mixed with them. (For example, rumors of Canine tranquilizer tablets being sold as MDMA)

If you could be certain of the absolute purity of the above mentioned chemicals, what would the health risks of ingesting each be?

Also, while some might consider sensory impairment a health risk, please do not bother to note that as that seems to be the desired effect among those who take these chemicals.

There are numerous. LSD is suspected to create permanent mutation within brain tissues, as well as others, and may impair in the physical functioning of necessary life support systems (hence the possibility of overdose). Most notably, a side effect of LSD involves spasm of the involuntary muscle groups (women who report giving birth to alien babies or the like often experience intensely painful uterine contractions), and hyperthermia which may bring on death due to thermal destruction of sensitive tissues.

Psilocybin is suspected to have some effect upon the cardiorespiratory system (though whether it is as a stimulant or depressant is unknown). It has a high LD50, so overdose on shrooms alone is rare. It is metastasized in the liver, allowing the possibility of liver damage especially during interaction with substances such as MAOI inhibitors and other psychotropic substances (including prescription).

MDMA is strongly suspected to be responsible for juvenile-onset schizophrenia. MDMA has been clinically demonstrated to destroy dura matter - literally it eats holes in one's brain. There is also the potential for significant dehydration. Combined with a typical amphetamine effect of raising metabolic temperature, and there is the danger of hyperpyrexia. Kids have been taken out of clubs in convulsions and found to have sustaining body temperatures above 107 degrees F, which can destroy muscular tissue including cardiac and renal tissues, and may be fatal if untreated. Ulcers (both internal and skin lesions) are common due to the toxicity of the substance, and addiction sets in rapidly.

Since you're discounting sensory impairment as a health risk - something no public health practitioner could in good conscience do, given the injuries brought about by intoxicated persons - I don't think you'll read beyond this statement, but I hope you do. The vast majority of injuries and fatalities from 'club drugs' is from what users do to themselves or others while on a trip. It's an ugly thing to have a freshman who thinks he can fly jump out of the 22nd story of his dorm tower. It's awful to see a high school athlete jump through a plate glass window because he can feel no pain while his neural receptors are blocked by PCP. You can discount them if you want - put the users in a padded cell or some such safe environment as advocated by the late though insane Timothy Leary - but the risks are real and they are there.

Considering how it affects everyone, you need to think about how people do stupid **** while on drugs. But if you know your mind and are comfortable with doing drugs and know you won't do anything crazy, you can discount those possibilities Report It

DEATH, Just smoke healthy "drugs" like God's herb. :)

I can't speak to MDMA. I know that LSD and psilocybin are completely harmless -- I and most of my friends at a certain stage of life used them extensively with no ill effects whatsoever -- except insofar as they can lead to radical changes in one's metaphysical worldview.

The stuff about mutation from LSD is absolute nonsense, pathetic 1960s antidrug propaganda, and I challenge anyone to come up with any actual epidemiological evidence to the contrary. I notice that Veritatum17's assertions are completely undocumented. Let's see the literature, if any of that stuff is true.

MDMA eats holes in your brain? That's a new one. The risks of pure MDMA are moderate, unless, like any substance, you abuse it.
The biggest risk is memory loss which increases with how frequently you use it.