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Does monocytes with LDL make form cells to block artery blood flow? please give me simple answer?


Does monocytes with LDL make form cells to block artery blood flow? please give me simple answer?

Oxidized LDL is small and dense, and able to be gathered from the blood by monocytes that become embedded in damaged parts of artery walls. As these increase in size, it can further split the artery wall, causing more embedding of more monocytes, gathering more LDL, making a worse and worse blockage.

Un-oxidized LDL is "big and fluffy", and the monocytes ignore it as it goes by. Having a lot of anti-oxidants in the blood can help keep this "safe" LDL from becoming the dangerous small dense LDL.

This is part of the inflamatory process that is seen at the intima portion of the artery of diseased arteries - and the pathophysiologic process of how plaques develop over time.

With acute MI's, the arterial lining ruptures prompting a cascade of clotting factors to be activated and an acute occlusion within the artery. The plaques that rupture typically have a thin fiborous cap with a lipid core underneath. More stable plaques (but sometimes more stenotic) have a thick fiborous cap.

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