Is huntington's disease...?

Sex-linked, autosomal recessive, or autosomal dominant?

Please help

It is autosomal dominant. The disease does not start until later in life. It is actually caused by an expansion of DNA in the Huntington Disease gene. The larger the expansion, the sooner in life the disease starts. Individuals with Huntington disease have a 50% chance of passing it on to their children, no matter if they are sons or daughters. I hope this answers your question. :)

Its autosomal dominant, as regards to it being sex linked, i'm not sure what you mean.

Huntington's disease is autosomal dominant, needing only one affected allele from either parent to inherit the disease. Although this generally means there is a one in two chance of inheriting the disorder from an affected parent, the inheritance of HD and other trinucleotide repeat disorders is more complex.

When the gene has more than 36 copies of the repeated trinucleotide sequence, the DNA replication process becomes unstable and the number of repeats can change in successive generations. This can mean that in a parent without HD but with a count close to 36, the count may increase above the threshold that causes HD.

If the gene is inherited from the mother, the count is usually similar. Paternal inheritance tends to increase the number of repeats.[4] Because of the progressive increase in length of the repeats, the disease tends to increase in severity and have an earlier onset in successive generations. This is known as anticipation.

De novo mutations (neither parent has HD) are rare.

Homozygous individuals (where both parents have HD) generally do not show an earlier onset of disease, but may have an increased rate of decline. George Huntington's 1872 paper described the disorder.
ICD-10 G10., F02.2
ICD-9 333.4, 294.1
OMIM 143100
DiseasesDB 6060
MeSH D006816
Huntington's disease, known historically as Huntington's chorea and chorea maior, is a rare inherited neurological disorder affecting up to approximately 1 person per 10,000 people of Western European descent and 1 per 1,000,000 of Asian and African descent. It takes its name from the New York physician George Huntington who described it precisely in 1872 in his first medical paper. HD has been heavily researched in the last few decades and it was one of the first inherited genetic disorders for which an accurate test could be performed.

Huntington's disease is caused by a trinucleotide repeat expansion in the gene coding for Huntingtin (Htt) and is one of several polyglutamine diseases. This expansion produces an altered form of the Htt protein, mutant Huntingtin (mHtt), which results in neuronal cell death in select areas of the brain. Huntington's disease is a terminal illness.

Huntington's disease's most obvious symptoms are abnormal body movements called chorea and a lack of coordination, but it also affects a number of mental abilities and some aspects of personality. These physical symptoms occur in a large range of ages, with a mean occurrence in a person's late forties/early fifties. If the age of onset is below 20 years then it is known as Juvenile HD. As there is currently no proven cure, symptoms are managed with various medications and care methods.