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What are 5 diseases similar to Hodgkin's disease?


Hi I was curious what are 5 disease similar to Hodgkin's Disease, can you tell me some answers please and thank you!

There are many other types of Lymphoma, they are called non-hodgkins lymphomas.


Differential Diagnosis

Non-neoplastic processes
Reactive immunoblastic processes
Kikuchi lymphadenitis
Blastic lymphomas
Burkitt lymphoma
Lymphoblastic lymphoma
Other B lineage lymphomas
Diffuse mixed lymphoma
Paraimmunoblastic SLL/CLL
Large cell transformation of SLL/CLL
Plasmablastic lymphoma
KSHV-associated germinotropic lymphoproliferative disorder
Other lymphomas
True histiocytic lymphoma
Classical Hodgkin lymphoma
Lymphocyte predominant Hodgkin lymphoma
Anaplastic large cell lymphoma
Reactive immunoblastic processes may simulate DLBCL

Most common causes are mononucleosis, other viruses, vaccination and drug reaction
Any of the following favor a reactive process
History or clincal evidence of any of the above causes
Age under 20 years
Polymorphous infiltrate with immunoblastic large cells
Partial node involvement
Mixed B and T phenotype of large cells
Light chain polytypia in large cells
CD30 may be seen in both neoplastic and reactive processes
EBV is rare in DLBCL except in immunosuppressed patients
Its presence suggests mononucleosis or other reactive conditions
Immunoglobulin gene rearrangement study may be neccesary in difficult cases


Kikuchi lymphadenitis may simulate DLBCL

Patchy pale foci composed of histocytes and karyorrhectic debris
Atypical activated large lymphocytes predominantly peripheral
Most large cells T lineage
Plasmacytoid dendritic cells (plasmacytoid monocytes) may be present
No sheets of large B cells on CD20 stain
Extracapsular extension rare

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