Does anyone have hemophilia without a dad who also has it?

If so, what causes it and do the factors replacements work well for you?

If you are a girl and your father has hemophilia you could have hemophilia. the disorder is passed down on the X chromosome as you know. Usually the mother who passes it on does not have symptoms. Right?

Females possess two X-chromosomes, whereas males have one X and one Y chromosome. Since the mutations causing the disease are recessive, a woman carrying the defect on one of her X-chromosomes may not be affected by it, as the equivalent allele on her other chromosome should express itself to produce the necessary clotting factors. However the Y-chromosome in men has no gene for factors VIII or IX. If the genes responsible for production of factor VIII or factor IX present on a male's X-chromosome is deficient there is no equivalent on the Y-chromosome, so the deficient gene is not masked by the dominant allele and he will develop the illness.

Since a male receives his single X-chromosome from his mother, the son of a healthy female silently carrying the deficient gene will have a 50% chance of inheriting that gene from her and with it the disease; and if his mother is affected with haemophilia, he will have a 100% chance of being a haemophiliac. In contrast, for a female to inherit the disease, she must receive two deficient X-chromosomes, one from her mother and the other from her father (who must therefore be a haemophiliac himself). Hence haemophilia is far more common among males than females. However it is possible for female carriers to become mild haemophiliacs due to lyonisation of the X chromosomes.

here's a chart
http://upload.wikimedia.org/wikipedia/co...

hi alex, was just thinking that you might find the work of gregor mendel interesting; perhaps you already know him. here's the quik easy version http://en.wikipedia.org/wiki/M... Report It

Hemophilia is passed through the female not the male.That is correct,women do not have the disease,they can but,do not always pass it on.I hope this helps.