What is the role of ACE_I in congestive heart failure?

i want to know the role of ACE_I IN CONGESTIVE heart failure specielly in kidney

Congestive heart failure is a condition in which the heart is unable to pump a sufficient amount of blood throughout the body.This can be due to high peripheral resistance(arterial resistance).
In the kidney there is something called the juxtaglomerular apparatus,which is responsible for the synthesis of renin.Renin gets converted into angiotensin 1 via an enzyme called angiotensinogen.Angiotensin 1 later gets converted into Angiotensin-2,via the angiotensin converting enzyme(ACE).Angiotensin 2 causes vasoconstriction thus increasing peripheral resistance making it difficult for the heart to pump blood
Therefore when we give ACE inhibitors,they will inhibit the ACE.Thus no angiotensin 2 is produced.No angiotensin 2 means no vasoconstriction which means there decrease in peripheral resistance,making it easier for the heart to pump blood.

it lowers blood pressure = lowers peripheral resistance = lowers cardiac contractility = better overall heart function = no more congestive heart failure

the therapeutic effect is not associated with the kidney...unless you're talking about the inhibition of aldosterone by the ACEI...but that just leads back to lowering blood pressure.

Tags

　　Heel Injuries 　　Heartburn 　　Heart Valve Diseases 　　Heart Transplantation 　　Heart Surgery 　　Heart Murmur 　　Heart Failure 　　Heart Defects 　　Heart Attack 　　Hearing Problems 　　Hearing Disorders 　　Health Insurance 　　HDL

Related information

Can anyone tell me if there is a connection between heart murmur, Raynauds, heart failure?

I THINK THE BEST PERSON TO THROW LIGHT ON THIS WOULD BE YOUR DOCTOR.. NOT THE LUNATICS ON HERE

...

Decayed tooth broke, root canal needed should i wait with heart failure?

You're on antibiotics, presumably for 7-10 days so you're ok until Dr. Wei returns..... chances are that if the root canal treatment is successful, a crown lengthening, core w/ possible p...

When you experience having redness evrytym you feel that your heart beats fast,is it heart failure?

This is NOT the presentation of heart failure. But they are the symptoms of an irregular fast heartbeat called ARRYTHMIA uccurimg episodically. My best advice to you is to consult your doctor...

How can I specify to donate my heart (upon death) to a friend who has heart failure?

You could do your friend more good by motivating others to become donors. Your sentiment is honorable, but the reality is there are a lot more people in need of organs than there are donors. If a...

Heart Failure and Abscessed tooth?

Oh yes it can! There are many documented cases of patients who have had mild to moderate untreated dental infections that lead to serious, and even fatal heart complications. Our mouths are very d...

Congestive heart failure...?

I looked this up about congestive heart failure for you, I have had it many time. I am a severe heart patient. Heart failure becomes more common with advancing age. You are also at increased ri...

My dad has Congestive Heart Failure and was just rushed to the hospital?

He is depressed and frustrated. Heart problems are very difficult to cope with because you really can't lead a normal life. Your activities are limited. You can eat the way you used to. Everyt...

Can congestive heart failure just start and then go away within a few weeks?

the symptoms can come and go. but i think that once you are diagnosed with it, you are always at more risk. so you have to watch for signs like chest pain, chest heaviness, difficulty breathing, ...