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What is Metylene-tetra-hydro-folate-re... |
its also known at MTHFR MUTATION High homocystine levels... http://www.kimballgenetics.com/tests-mth... Im not sure what Wiki is saying, but I know that what you want to know is in that link. Hope it helps. Do you mean "methylenetetrahydrofolatereductase (MTHFR)"? Four different dehydrogenases are known that catalyze the reversible dehydrogenation of N5,N10-methylenetetrahydro methanopterin (methylene-H4MPT) or N5,N10-methylenetetrahydrofolate (methylene-H4F) to the respective N5,N10-methenyl compounds. Sequence comparisons indicates that the four enzymes are phylogenetically unrelated. They all catalyze the Re-face stereo-specific removal of the pro-R hydrogen atom of conenzyme's methylene group. The Re-face stereospecificity is in contrast to the finding that in solution the pro-S hydrogen atom of methylene-H4MPT and of methylene-H4F is more reactive to heterolytic cleavage. For a better understanding we determined the conformations of methylene-H4MPT in solution and when enzyme- bound by using NMR spectroscopy and semiempirical quantum mechanical calculations. For the conformation free in solution we find an envelope conformation for the imidazoline ring, with the flat at N10. The methylene pro-S C-H bond is anticlinal and the methylene pro-R C-H bond is synclinal to the lone pair of N10. Semiempirical quantum mechanical calculations of heats of formation of methylene-H4MPT and methylene-H4F indicate that changing this conformation into an activated one in which the pro-S C-H bond is antiperiplanar, resulting in the preformation of the leaving hydride, would require a 螖螖Hfo of 53 kJ mol-1 for methylene-H4MPT and of 51 kJ mol-1 for methylene-H4F. This is almost twice the energy required to force the imidazoline ring in the enzyme-bound conformation of methylene-H4MPT (+29 kJ mol-1) or of methylene-H4F (+35 kJ mol-1) into an activated conformation in which the pro-R hydrogen is antiperiplanar to the lone electron pair of N10. The much lower energy for pro-R hydrogen activation thus probably predetermines the Re-face stereospecificity of the foue dehydrogenases. Results are also presented explaning why the chemical reduction of methenyl-H4MPT and methenyl-H4F with NaBD4 proceeds Si-face-specific, in contrast to the enzyme-catalyzed reaction. |
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Folate, also referred to as folic acid or folacin, this vitamin B complex is converted into enzymes that the body needs to make DNA, RNA and red blood cells, and to carry out other important metabo... Dosage - For overall good health and the prevention of heart disease: 400 to 800 mcg of folic acid a day. For women who might become pregnant: a total of 800 mcg a day. (Adequate folic ac... they say women of child bearing age to take folate just in case you get pregnant. if you get pregnant and have low levels of folate, the baby can be born with a lot of abnormalities dealing with th... Nope, it means you are getting enough folic acid and if you are a woman that is perfect! Don't be alarmed. Pat yourself on the back for getting enough folate in your diet. ...the function of and synthesis of dna in cells and replication ,if deficient neural tubal defects may arise ...Have you heard of Iron Overload? Most conventional doctors do not check for it(there is a special equation to figure it out) or know much about it. Your test results can come back with low iron..... wow!!! life is way to short to worrie about every carrot stick you eat, as long as you exorsise often and raise your heart rate a little from time to time, drink plenty of water and milk and juice,... Do your own homework. ... |
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