Does anyone or anyone you know have to be on hormone replacement therapy?

Because that person is so low on estrogen, petuitary works fine, the doctors have to induce her puberty and she's been on hormone replacement therapy for 5 years to produce estrogen?

It's that rare huh?

If you know that person does that person have trouble with getting aroused at all?

I was on HRT for over 30 years. I felt fine and I had a great life and career. You don't state your age or this person's age. If they are a teen, why are you worried about their sexual arousal? All Estrogen does is make the body function like it should. All organs depend on it. Talk to the OBGYN or doctor that prescribed it if you don't understand the reasoning behind the therapy. This is not a rare condition. Talk your doctor face to face and get the facts.

My mom was on estrogen but as far as I know, her sex life was fine. She talked about it freely (yes, poor me). All I know is, you should stop estrogen ASAP because it hightens the risk for breast cancer by ALOT. That is what my mom had to do. It will throw you straight into menopause and put everyone into a living hell even though you dont realize it, but its for the best. Just remember, its you, not them. But they still love you.

I am on HRT. Hormone replacement therapy does not cause menopause. It is a treatment for menopause. Estrace by itself is not bad at all. It is the combination pills that are more dangerous. BTW, there are no problems in the arousal department for me.
I have never heard of estrace being used for puberty.