A 45 year old hypertensive diabetic female,complaints of fever,decreased micturition kidney transplant history

a 45 year old hypertensive,diabetic female came to emergency with complaints of fever, decreased micturition and tenderness in the muber region for 24 hours. she has a history of transplantation of kidney 2 weeks back, due to end stage renal disease. she was also on immuno spuressive therapy. she had all vitals high. had pedal edema, auscultation crackles present bilaterally, perorbital puffiness, high urea and creatinine values. Renal biospy was done to see her condition. can you please tell me the patho physiological mechanism for the development of the above sign & symptoms.

Let me start by saying I'm no doctor, although I do have experience with kidney transplantation, having undergone the procedure twice. Your query states that the patient underwent transplantation two weeks ago, and is suffering high creatinine, urea (BUN), edema, and high vitals. From my experience, this sounds much like acute rejection, which is somewhat common in the early post-transplant stages, and can often occur within the first six months post-transplant. It is also possible that the organ is in chronic rejection; that is, dying off, but that would most likely be caused by lack of taking immunosuppressive therapy, or insufficient immunosuppressive therapy. Again, I'm no doctor, just going on my personal experience and what I've learned about the transplant condition.

Do your own homework!

Yep. Acute rejection. Your patient now is also in a very serious state additionally due to having no renal function and receiving no dialysis treatment. There may also be an infection present as result of the surgery and the immuno-suppressant regime.

You really need to do your own homework!! How are you going to treat your patients?! This really is a very easy question!