Okay heres the thing I have pain in my hands,wrist,elbows,and shoulders and my doctor said that is may be carpal tunnel but then I went back a year later because I still have pain almost everyday day now and she said she wasn't sure so I am going to see an hand/orthapedic surgeon and specialist. But then the other day I post a question on here and someone told me ask my doctor about "Mixed Conntective Tissue Disorder that has rheumtoid arthritis involved" because he had similar problems with his arms so I looked it up online and they said it had do with lupus so this is why I was asking if it ran in families because I have someone in my family with it and I was wondering if it would be a good idea to ask my doctor about it when I see him in march? I am only 17 so I really would like to figure out the problem before it just gets worse you know? There are three mechanisms by which lupus is thought to develop: genetic predisposition, environmental triggers and drug reaction (drug-induced lupus).
Genetics- The first mechanism may arise genetically. Research indicates that SLE may have a genetic link. Lupus does run in families, but no single "lupus gene" has yet been identified. Instead, multiple genes appear to influence a person's chance of lupus developing when triggered by environmental factors. The most important genes are located on chromosome 6, where mutations may occur randomly (de novo) or be inherited. Additionally, people with SLE have an altered RUNX-1 binding site, which may be either cause or contributor (or both) to the condition. Altered binding sites for RUNX-1 have also been found in people with psoriasis and rheumatoid arthritis. (Wikipedia)
Often other family members will also have lupus or other immune system-related illnesses, known autoimmune diseases, such as rheumatoid arthritis.(BBC News)
Please see the web pages for more details on Systemic Lupus Erythematosis. |
