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Why wouldn't plasmaphoresis work for a chronic EBV infection?


I don't really see this working, but if in theory its possible I'd like to try it. I have extremely high viral load, it would remove some of the *antibodies* but that wouldn't help

Let alone the risks of having Plasmaphoresis! It is not just a simple task of removing the blood cleaning it and returning it, the risks are serious.

I think you've answered your own question rather well.

Plasmapheresis removes the liquid portion of the blood and returns the cells (red, white and some platelets) to the donor.
Remember that blood plasma is 98% water. The remainder is protein, carbohydrates, fat. Antibodies are protein so you lose them too as you've already noted.

EBV (Epstein-Barr Virus) is an obligate intercellular organism. So removing the plasma would not remove the virus. Even if it did remove a few virus particles, the virus is always replicating so they are replaced quickly.

If fact, I would suggest not to have any plasmapheresis. You're better off with your antibodies than without.

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