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From where this dengue virus came?


ive got enought information on dengue virus n what it does...but i wanna know its origin

Dengue virus (DENV) infection is recognized as a major public health problem; >50 million persons are infected each year worldwide, and the incidence of severe, sometimes lethal, forms of the disease is increasing. Dengue viruses are mosquitoborne flaviviruses with a single-stranded, nonsegmented, positive-sense RNA genome 鈮?1 kb in length. Four antigenically distinct serotypes, DENV types 1 to 4, exist. Infection with any serotype can lead to disease, ranging from mild infection, dengue fever (a generally mild disease with complete recovery), to severe forms (dengue hemorrhagic fever and dengue shock syndrome). Molecular epidemiologic studies have investigated the possibility of a link between particular DENV genotypes or clusters and particular clinical forms of disease. Consequently, finding new viral genotypes in areas where they had been absent could be of epidemiologic and clinical interest. A recent work described the emergence and the global spread of DENV-3 subtype III.

Originating from the Sri Lankan/Indian subcontinent, the new variant likely spread to eastern Africa in the 1980s, then to Latin America in the mid-1990s. Previous work in our laboratory identified a DENV-3 subtype 3 of the same origin in Martinique in 1999.

Whereas other Caribbean islands had annual dengue epidemics, the last outbreak reported in Saint Martin (French West Indies) (Figure 1) was in 1977 (7). Only DENV-1 was isolated during this epidemic, while DENV-1, DENV-2, and DENV-3 circulated in Puerto Rico at the same time.

In 2000, during an interepidemic period, 1 isolate of DENV-3 was reported in Saint Martin(http://www.carec.org/annrep00/index.html... but to our knowledge its sequence was not determined. During the last 3 years, no further DENV isolates have been reported on the island.

However, in December 2003, an outbreak of febrile illness was reported after heavy rains. An estimated 108 persons were infected, and DENV was suspected to be the causative agent by Saint Martin Lepers Laboratory (9). During this period, blood samples collected at early and late stages of infections were examined at the Tropical Medicine Institute of the French Armed Forces Medical Service (Institut de M茅decine Tropicale du Service de Sant茅 des Arm茅es [IMTSSA]) tropical virology laboratory in Marseille to identify the etiologic agent. DENV-3 was isolated on C6/36 cells (Aedes albopictus). Partial genomic sequences were determined for each isolated virus to evaluate the origin and diversity of its spread. This approach should help clarify the geographic distribution of isolates in the Caribbean islands as well as the virus' circulation in and transmission to humans.

It is transmitted by mosquitos, if that is what you ask. If your interested in the evolutional origin of the species, I'm afraid that's not exactly known in detail:)

aedes aegypti. usually in tropical climate

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