How cystic fibrosis is controlled by arecessive gene?

how cystic fibrosis is controlled by arecessive gene

I don't understand your use of the word controlled.
If you mean what is the relationship of recessive genes to Cystic Fibrosis?
Because the trait for CF is attached to a recessive gene it means that when that gene is passed on to a child it is harmless on its own. The disease only occurs when one woman with the recessive linked gene mates with a male with the same recessive gene. Two recessives result in the disease happening in the child.
The two parents who only have half the material each on their genes are ''carriers'' of the disease.
Most cystic fibrosis children are blond and blue eyed because these too are thought to be part of recessive genes.
Is that what you want to know?

All I know is 2 of my cousins died from it and 3 siblings are fine..It hit the first and last child in family but not 3 in middle

The gene involved in cystic fibrosis produces a protein that acts as a tunnel and gate to regulate the passing of chloride ions through the outer membrane of a cell.

In a person with two "normal" copies of this gene, the blueprints to build this tunnel are present on both of the #7 chromosomes.

In a person who is a carrier, one normal gene and one defective gene are present. The defective gene has inaccurate blueprints. Depending upon the exact defect, either a defective tunnel gets built or possibly none at all using these blueprints. But the normal gene still has accurate blueprints for building this tunnel and chloride ions are still able to pass through the cell membrane.

But in a person with two defective copies of this gene, the tunnel cannot be built correctly. Transportation of chloride ions is disrupted and this results in a disease process known as cystic fibrosis.

Since the disease process is avoided with even just one correct copy of the gene, it takes both genes to be bad before a person has CF.

It takes two, just like blue eyes; one from Mom and one from Dad.

See http://www.cff.org/AboutCF/Faqs/ for the answer to this and many other related questions.

Tags

　　Deep Vein Thrombosis 　　Decubitus Ulcers 　　Deafness 　　Cytomegalovirus 　　Cystitis 　　Cystic Fibrosis 　　Cushing Syndrome 　　Cubital Tunnel Syndrome 　　CT Scans 　　Crutches 　　Croup 　　Crohn Disease

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