My family has 3 with hypertrophic cardiomyopathy, my daughter is going to have a baby can the baby get it?

My mother has it, my brother died from it and his daughter (my Niece)has it, so if i'm not affected and my daughter isn't, what are the chances that her unborn child will be?

Hypertrophic cardiomyopathy is a autosomal dominant disease most of the time. Which means that it only takes one gene to pass it along. if your parent is affected it you would have a 50% change of getting it. Since you and your daughter both dont have it it is unlikely that her child will have it. However there are exceptions it would be helpful to see a genetic counsler

i think 1 out of 3

Hypertrophic cardiomyopathy or HOCM is a heterogeneous disorder with multiple different mutations or (gene changes) responsible for causing it. The likelihood of inheritance is related to the particular genetic mutation and needs to be tested to determine the chance of propagation. Depending upon the type of mutation it can skip a generation or two. The easiest thing would be for the child to have an echo or ultrasound in infancy and later as a teen.

I would recommend that your daughter see a specialist in maternal-fetal medicine and have a detailed ultrasound done (of the baby). Although HOCM is often not manifest until the person is older, in some cases it might be picked up prenatally.