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Alzheimer's? |
If a family member (Father/Mother) suffered from alzheimer's, what are the chances of their children being affected? Unfortunately, 15% of the victims of Alzheimer's disease have a family history of the disease, occasionally with a dominant pattern of interitance (in which children with one affected parent have a 50% chance of inheriting the disease). The cause of Alzheimer's disease is unknown but a number of theories have been proposed, ranging from the effects of chronic infection to toxic poisoning by a metal such as aluminum. There are some drugs, such as Aricept, that show promise in slowing the progression of the disease but there is no cure as of yet. Quite a lot I would think. I think I am half way there already There are different 'types'. One is more likely than the other. If you're concerned, start doing all those things you know you ought to: exercise, fish, crossword puzzles, socialising, fresh veg (lots) (check out 'green for life' by Victoria Butenko) Familial (Hereditary) Alzheimer鈥檚 disease (FAD) is a rare form of the disease, affecting less than 10 percent of Alzheimer鈥檚 disease patients. All FAD is early-onset, meaning the disease develops before age 65. It is caused by gene mutations on chromosomes 1, 14, and 21. Even if one of these mutated genes is inherited from a parent, the person will almost always develop early-onset Alzheimer鈥檚 disease. All offspring in the same generation have a 50/50 chance of developing FAD if one of their parents had it. The majority of Alzheimer鈥檚 disease cases are late-onset, usually developing after age 65. Late-onset Alzheimer鈥檚 disease has no known cause and shows no obvious inheritance pattern. However, in some families, clusters of cases are seen. Although a specific gene has not been identified as the cause of late-onset Alzheimer鈥檚 disease, genetic factors do appear to play a role in the development of this form of the disease. The ApoE gene on chromosome 19 has three forms鈥擜poE2, ApoE3 and ApoE4. Studies have shown that people who inherit the E4 version of the gene are more likely to develop the late-onset form of Alzheimer鈥檚 disease. Scientists estimate that an additional four to seven genes influence the risk of developing late-onset Alzheimer鈥檚 disease. Two of these genes are UBQLN1 and SORL1, which are located on chromosomes 9 and 11, respectively. Genetic risk factors alone are not enough to cause the late-onset form of Alzheimer鈥檚 disease, so researchers are actively exploring education, diet, and environment to learn what role they might play in the development of this disease. My nan had Alzheimer's and when i spoke to my GP she told me it can run in the family but it is rare. I'm not sure if you're talking about the challenges face with a family member suffering from the disease or if you talking about inheriting the disease. But here is a great article about |
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